Transcriptional control of T cell development.
|Title||Transcriptional control of T cell development.|
|Publication Type||Journal Article|
|Year of Publication||2000|
|Journal||Current opinion in immunology|
|Date Published||2000 Jun|
|Abstract||Transcriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally, a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted.|
|Alternate Journal||Curr. Opin. Immunol.|