Transcriptional control of T cell development.

TitleTranscriptional control of T cell development.
Publication TypeJournal Article
Year of Publication2000
AuthorsOsborne BA
JournalCurrent opinion in immunology
Volume12
Issue3
Pagination301-6
Date Published2000 Jun
AbstractTranscriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally, a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted.
Alternate JournalCurr. Opin. Immunol.