TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells.

TitleTCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells.
Publication TypeJournal Article
Year of Publication2003
AuthorsPalaga T, Miele L, Golde TE, Osborne BA
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume171
Issue6
Pagination3019-24
Date Published2003 Sep 15
AbstractNotch genes encode membrane receptors that regulate cell fate decisions in metazoa. Notch receptors and ligands are expressed in developing lymphoid tissue and mature lymphocytes and the role of Notch signaling in early T and B cell development has been studied extensively. However, its contribution to mature T cell function is unknown. TCR-mediated T cell activation is a fundamental process of the adaptive immune system that has been studied for decades; however, the details of this process are incompletely understood. In this study, we present evidence that Notch is required for TCR-mediated activation of peripheral T cells. Inhibition of Notch activation dramatically decreases T cell proliferation in both CD4 and CD8 cells and blocks both NF-kappaB activity and IFN-gamma production in peripheral T cells. Our data reveal a new, nondevelopmental function of Notch as a previously unknown key link in peripheral T cell activation and cytokine secretion.
Alternate JournalJ. Immunol.