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Pregnancy offers new insights into mechanisms of breast cancer risk and resistance.
| Title | Pregnancy offers new insights into mechanisms of breast cancer risk and resistance. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Jerry JD, Makari-Judson G, Crisi GM, Dunphy KA |
| Journal | Breast Cancer Res |
| Volume | 15 |
| Issue | 5 |
| Pagination | 312 |
| Date Published | 2013 |
| ISSN | 1465-542X |
| Keywords | Breast Neoplasms, Cell Lineage, Cyclin-Dependent Kinase Inhibitor p27, Female, Gene Expression Profiling, Humans, Mammary Glands, Human, Parity, Pregnancy, Stem Cells |
| Abstract | Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent studies focus attention on progenitor cells as major targets. The results suggest new biomarkers that may improve risk prediction and provide endpoints for assessment of clinical responses to prophylactic therapies. |
| DOI | 10.1186/bcr3482 |
| Alternate Journal | Breast Cancer Res. |
| PubMed ID | 24060354 |