Notch signalling during peripheral T-cell activation and differentiation.

TitleNotch signalling during peripheral T-cell activation and differentiation.
Publication TypeJournal Article
Year of Publication2007
AuthorsOsborne BA, Minter LM
JournalNature reviews. Immunology
Volume7
Issue1
Pagination64-75
Date Published2007 Jan
AbstractFor many years, researchers have focused on the contribution of Notch signalling to lymphoid development. Only recently have investigators begun to ask what role, if any, Notch has during the activation and differentiation of naive CD4(+) T cells in the periphery. As interest in this issue grows, it is becoming increasingly clear that the main role of Notch signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells.
Alternate JournalNat. Rev. Immunol.