Induction of genes during apoptosis: examples from the immune system.

TitleInduction of genes during apoptosis: examples from the immune system.
Publication TypeJournal Article
Year of Publication1995
AuthorsOsborne BA
JournalSeminars in cancer biology
Volume6
Issue1
Pagination27-33
Date Published1995 Feb
AbstractThe immune system provides many examples of cell populations that are susceptible to the induction of apoptosis. Self-reactive immature cells are deleted by triggering apoptosis. Additionally, mature peripheral lymphocytes are induced to undergo apoptosis, particularly when hyperactivated. In the past few years, several genes have been linked to cell death in lymphoid cells. However, only a handful of these genes has been shown to be required for cell death to occur in the immune system. This review focuses on signals known to mediate apoptosis in the immune system and those genes demonstrated to be required for the induction of cell death.
Alternate JournalSemin. Cancer Biol.