Evolution of the CD163 family and its relationship to the bovine gamma delta T cell co-receptor WC1.

TitleEvolution of the CD163 family and its relationship to the bovine gamma delta T cell co-receptor WC1.
Publication TypeJournal Article
Year of Publication2010
AuthorsHerzig CTA, Waters RW, Baldwin CL, Telfer JC
JournalBMC evolutionary biology
Volume10
Pagination181
Date Published2010
AbstractThe scavenger receptor cysteine rich (SRCR) domain is an ancient and conserved protein domain. CD163 and WC1 molecules are classed together as group B SRCR superfamily members, along with Spalpha, CD5 and CD6, all of which are expressed by immune system cells. There are three known types of CD163 molecules in mammals, CD163A (M130, coded for by CD163), CD163b (M160, coded for by CD163L1) and CD163c-alpha (CD163L1 or SCART), while their nearest relative, WC1, is encoded by a multigene family so far identified in the artiodactyl species of cattle, sheep, and pigs.
DOI10.1002/jcp.22409
Alternate JournalBMC Evol. Biol.