Do all programmed cell deaths occur via apoptosis?

TitleDo all programmed cell deaths occur via apoptosis?
Publication TypeJournal Article
Year of Publication1993
AuthorsSchwartz LM, Smith SW, Jones ME, Osborne BA
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue3
Pagination980-4
Date Published1993 Feb 1
AbstractDuring development, large numbers of cells die by a nonpathological process referred to as programmed cell death. In many tissues, dying cells display similar changes in morphology and chromosomal DNA organization, which has been termed apoptosis. Apoptosis is such a widely documented phenomenon that many authors have assumed all programmed cell deaths occur by this process. Two well-characterized model systems for programmed cell death are (i) the death of T cells during negative selection in the mouse thymus and (ii) the loss of intersegmental muscles of the moth Manduca sexta at the end of metamorphosis. In this report we compare the patterns of cell death displayed by T cells and the intersegmental muscles and find that they differ in terms of cell-surface morphology, nuclear ultrastructure, DNA fragmentation, and polyubiquitin gene expression. Unlike the T cells, which are known to die via apoptosis, we find that the intersegmental muscles display few of the features that characterize apoptosis. These data suggest that more than one cell death mechanism is used during development.
Alternate JournalProc. Natl. Acad. Sci. U.S.A.