Cutting edge: protective effects of notch-1 on TCR-induced apoptosis.

TitleCutting edge: protective effects of notch-1 on TCR-induced apoptosis.
Publication TypeJournal Article
Year of Publication1999
AuthorsJehn BM, Bielke W, Pear WS, Osborne BA
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume162
Issue2
Pagination635-8
Date Published1999 Jan 15
AbstractThe Notch receptor protein was originally identified in Drosophila and is known to mediate cell to cell communication and influence cell fate decisions. Members of this family have been isolated from invertebrates as well as vertebrates. We isolated mouse Notch-1 in a yeast two-hybrid screen with Nur77, which is a protein that has been shown previously to be required for apoptosis in T cell lines. The data presented below indicate that Notch-1 expression provides significant protection to T cell lines from TCR-mediated apoptosis. These data demonstrate a new antiapoptotic role for Notch-1, providing evidence that, in addition to regulating cell fate decisions, Notch-1 can play a critical role in controlling levels of cell death in T cells.
Alternate JournalJ. Immunol.