Ca2+ signaling during maturation of cumulus-oocyte complex in mammals.

TitleCa2+ signaling during maturation of cumulus-oocyte complex in mammals.
Publication TypeJournal Article
Year of Publication2011
AuthorsSilvestre F, Boni R, Fissore RA, Tosti E
JournalMolecular reproduction and development
Date Published2011 Oct-Nov
AbstractUnder the influence of gonadotropins or growth factors, a close cooperation develops between cumulus cells and the oocyte that is implicated in transmitting signals involved in maintaining or releasing the meiotic arrest in the oocyte. While cyclic adenosine 5’-monophosphate (cAMP) is a key molecule in maintaining the meiotic arrest, calcium (Ca(2+)) may play a role in controlling either spontaneous or gonadotropin-induced oocyte maturation, possibly by modulating intracytoplasmic cAMP concentrations via Ca(2+)-sensitive adenylate cyclases. This review focuses on the mechanisms related to the origin of the Ca(2+) wave that travels from the cumulus cells to the oocyte, and discusses the source of variations affecting the dynamics of this wave.
Alternate JournalMol. Reprod. Dev.
PubMed ID21656870