Maria Gracia Gervasi

Maria Gracia Gervasi, Ph.D.

Research Assistant Professor

Office phone: 413-545-4050

Lab phone: 413-545-4050

Email: mariagracia [at] vasci [dot] umass [dot] edu

Office location: ISB 313

Mailing address:

661 North Pleasant Street
Amherst, MA 01003

Ph.D.: University of Buenos Aires, Argentina (2013)

Postdoctoral Training: University of Massachusetts, Amherst, MA.

Lalor Foundation Postdoctoral Fellow, 2013-2015

Collaborating PI
Pablo Visconti, PhD

ANIMLSCI 455 Research Animal
Management I
ANIMLSCI 456 Research Animal Management II

List of Publications:
Salicioni AM, Gervasi MG, Sosnik J, Tourzani DA, Nayyab S, Caraballo DA, Visconti PE. 2020. Testis-Specific Serine Kinase (TSSK) Proteins Family in Male Fertility and as Targets for Non-hormonal Male Contraception. Biology of Reproduction.

Alonso CAI, Lottero Leconte R, Luque GM, Vernaz Z, Di Siervi N, Gervasi MG, Buffone MG, Davio C, Perez Martinez S. Involvement of cAMP efflux, through MRP4 transporter, in the acquisition of fertilization ability of mouse spermatozoa. J Cell Science. 2019 Jul 26;132(14).

Romarowski A, Velazco A, Gervasi MG, Xu X, Torres Rodriguez P, Luque MG, Sanchez Cardenas C, Ramirez Gomez H, Krapf D, Visconti P, Krapf D, Guerrero A, Darszon A, Buffone MG. Super-resolution imaging of live sperm reveals specific dynamic changes of the actin cytoskeleton during acrosomal exocytosis. J Cell Science. 2018 Nov 8;131(21).

Paudel B, Gervasi MG, Porambo J, Caraballo D, Tourzani D, Mager J, Platt MD, Salicioni AM, and Visconti PE. Sperm capacitation is associated with phosphorylation of the testis-specific radial spoke protein Rsph6a. Biology of Reproduction. 2018 Sep 15.

Tourzani D, Paudel B, Miranda P, Salicioni AM, Visconti PE, Gervasi MG. Changes in protein O-GlcNAcylation during epiditymal maturation. Front Cell Dev Biol. 2018 Jun 11;6:60.

Gervasi MG, Xu X, Carbajal-Gonzalez B, Buffone MG, Visconti PE, Krapf D. The actin cytoskeleton of the mouse sperm flagellum is organized in a helical structure. J Cell Science. 2018 Jun 11;131(11).

Stival C, Ritagliati C, Xu X, Gervasi MG, Luque MG, Baró Graf C, de la Vega-Beltrán JL, Torres NI, Darszon A, Krapf D, Buffone MG, Visconti PE, Krapf D. Disruption of protein kinase A localization induces the acrosome reaction in capacitated mouse sperm. J Biol Chem. 2018 Jun 15;293(24):9435-9447.

Matamoros-Volante A, Moreno-Irusta A, Torres-Rodriguez P, Giojalas L, Gervasi MG, Visconti PE, Treviño CL. Semi-automatized segmentation method using image-based flow cytometry to study sperm physiology: the case of capacitation-induced tyrosine phosphorylation. Mol Hum Reprod 2018 Feb 1; 24(2):64-73.

Gervasi MG, Visconti PE. Molecular changes and signaling events occurring in sperm during epididymal maturation. Andrology. 2017 Mar;5(2):204-218. doi: 10.1111/andr.12320. Review.

Gervasi MG, Visconti PE. Chang’s meaning of capacitation: A molecular perspective. Mol Reprod Dev. 2016 Oct;83(10):860-874. Review.

Alvau A*, Battistone MA*, Gervasi MG, Navarrete FA, Xu X, Sánchez-Cárdenas C, De la Vega-Beltran JL, Da Ros VG, Greer PA, Darszon A, Krapf D, Salicioni AM, Cuasnicu PS, Visconti PE. (*equal contributors). The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm. Development. 2016 Jul 1;143(13):2325-33.

Gervasi MG, Osycka-Salut C, Sanchez T, Alonso C, Llados C, Castellano L, Franch AM, Villalón M, Perez-Martinez S. Sperm Release from the Oviductal Epithelium Depends on Ca2+ Influx Upon Activation of CB1 and TRPV1 by Anandamide. J Cell Biochem. 2016 Feb;117(2):320-33.

Caballero JN, Gervasi MG, Veiga MF, Dalvit GC, Perez-Martínez S, Cetica PD, Vazquez-Levin MH. Epithelial cadherin is present in bovine oviduct epithelial cells and gametes, and is involved in fertilization-related events. Theriogenology. 2014 Jun 81(9):1189-206.

Osycka-Salut C, Diez F, Burdet J, Gervasi MG, Franchi A, Bianciotti LG, Davio C, Perez-Martinez S. Cyclic AMP efflux, via MRPs and A1 adenosine receptors, is critical for bovine sperm capacitation. Mol Hum Reprod. 2014 Jan 20(1):89-99.

Gervasi MG, Marczylo TH, Lam PM, Rana S, Franchi AM, Konje JC, Perez-Martinez S. Anandamide levels fluctuate in the bovine oviduct during the oestrous cycle. PLoSOne. 2013 Aug 16; 8(8):e72521.

Sordelli MS, Beltrame JS, Cella M, Gervasi MG, Perez Martinez S, Burdet J, Zotta E, Franchi AM, Ribeiro ML. Interaction between lysophosphatidic acid, prostaglandins and the endocannabinoid system during the window of implantation in the rat uterus. PLoSOne. 2012 Sep 7(9):e46059.

Osycka-Salut C, Gervasi MG, Pereyra EN, Cella M, Ribeiro ML, Franchi A, Perez-Martinez S. Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. PLoSOne 2012 Feb 17;7(2):e30671.

Gervasi MG, Osycka-Salut C, Caballero J, Vazquez-Levin M, Pereyra E, Billi S, Franchi A and Perez-Martinez S. Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. PLoSOne 2011 Feb 11;6(2):e16993.

Gervasi MG, Rapanelli M, Ribeiro ML, Farina M, Billi S, Franchi AM and Perez-Martinez S. The endocannabinoid system in bull sperm and bovine oviductal ephitelium: role of anandamide in sperm-oviduct interaction. Reproduction 2009 Mar; 137(3):403-14. Epub 2008 Nov 28.