Leonid A. Pobezinsky
Leonid A. Pobezinsky, Ph.D.
Associate Professor

Office phone: 413-545-2393
Fax: 413-545-6326
Email: lpobezinsky [at] umass [dot] edu
Office location: 427G ISB
Mailing address:
661 North Pleasant Street
Amherst, MA 01003
Ph.D.: Cancer Research Center, Moscow, Russia, 2003
Postdoctoral Training:
Experimental Immunology Branch, NCI/NIH
Co-Investigator - Research Assistant Professor - Elena Pobezinskaya, PhD
Classes:
ANIMLSCI 572 - Infection & Immunity
ANIMLSCI 581/697C - Cancer Biology
ANIMLSCI 794A - Immunology Journal Club
Non-coding RNAs in the immune system
Our laboratory is interested in the molecular mechanisms that control differentiation and transformation programs within an organism. The immune system constantly undergoes differentiation and is prone to malignant transformation providing an excellent model to study these programs. Thus, the focus of the laboratory is to identify key regulators of genes that are critical for normal function and for tumorigenesis of the immune system. Recently, non-coding RNAs, miRNAs, have been shown to control expression of many genes at the transcriptional and post-transcriptional levels. Specifically, we would like to understand the function of tumor suppressive and oncogenic miRNAs that are expressed in the immune cells.
The Pobezinsky Lab has been awarded a $3.75 million grant from Nonpareil miRNA Accelerator LLC. With this grant, they propose to enhance the efficacy of cancer immunotherapies using a novel strategy that is based on miRNA-dependent T cell-intrinsic mechanisms of gene regulation.
Name | Phone | Office | |
---|---|---|---|
Ullom , Jake Graduate Student - MCB | jullom [at] umass [dot] edu | ISB 470 | |
Pobezinskaya , Elena Research Assistant Professor | pobezinskaya [at] umass [dot] edu | 413-545-2405 | 427ZA ISB |
Lynch , Adam Research Fellow | aclynch [at] umass [dot] edu | 413-545-2051 | ISB 470 |
Roberts , Eugenia Undergraduate Student | emroberts [at] umass [dot] edu | ISB 470 |