D. Joseph Jerry

D. Joseph Jerry

Professor

Science Director, Pioneer Valley Life Sciences Institute
Co-Director, Rays of Hope Center for Breast Cancer Research

Joe Jerry

Office phone: 413-545-5335

Fax: 413-545-6326

Email: jjerry [at] vasci [dot] umass [dot] edu

Office location: 427P ISB

M.S.: Purdue University
Ph.D.: The Pennsylvania State University
Postdoctoral Training:
Jackson Laboratory, Bar Harbor, Maine
Baylor College of Medicine, Houston, Texas

 

Classes:
FFYS 197ANML3 - What’s in your genes?
ANIMLSCI 581 - Cancer Biology
ANIMLSCI 697C - Cancer Biology
ANIMLSCI 697J - Genes, Cells and Development
  

 

  • Regulation of the p53 tumor susceptibility gene and susceptibility to breast cancer.
  • Methods for genetic modification of livestock.

Reproductive factors and family history of breast cancer are among the most consistent predictors of an individual’s risk of developing breast cancer. These observations emphasize the important contributions of both genetic background and hormonal exposures in determining the risk of breast cancer. Through the use of contemporary techniques in molecular and cellular biology with animal models and primary cultures of human breast cells, we are defining the cues that influence development of the breast epithelium and providing mechanistic insights into the genetic and cellular basis for susceptibility to breast cancer.

The p53 tumor suppressor protein is a major focus of the laboratory because of its pivotal role in cancer. In addition to its role in genome surveillance, we found that loss of p53 allows expansion of the mammary stem cell population and this can be reversed by inhibition of Notch. Surprisingly, the fundamental actions of p53 on genome surveillance are enhanced by hormonal stimuli during pregnancy and contribute to the reduction in mammary tumors afforded by a full-term pregnancy. Administration of exogenous estrogen was sufficient to mimic the effect of pregnancy. Although estrogen stimulates proliferation, it also potentiates the p53-mediated apoptosis. These duplicitous actions of estrogens appear to be regulated through distinct estrogen receptors alpha and beta. The genes that arbitrate the decisions of whether cells live or die in response to stress stimuli represent critical pathways determining risk or resistance to breast carcinogenesis. Selective activation of the genome surveillance actions can be harnessed for the prevention of breast cancer and adjuvant therapies forthose tumors with functional p53.

The frequent mutation of p53 in breast cancer reflects its critical role. However, in mice bearing mutations in p53, the incidence of mammary tumors differs dramatically among strains. Naturally-occurring variants in homology-directed DNA repair have revealed a profound role for this pathway in determining risk of mammary tumors. To translate these observations to humans, we have collaborated with clinicians and scientists at Baystate Medical Center to establish the Rays of Hope Breast Research Registry. Through this prospective cohort, we have consented nearly 1000 women and established primary breast epithelial cells from ~200 women. These resources allow us to define the mechanistic basis for differences in responses to exposures to estrogens and environmental chemicals that can predispose individuals to breast cancer. We are also studying the molecular basis for premalignancy using gene expression profiles from atypical ductal and lobular hyperplasias. These studies provide the basis for diagnostic tests defining which patients are at high risk and should consider treatments while also providing insights into the molecular basis for premalignancy in the human breast.

Jerry JD, Shull JD, Hadsell DL, Rijnkels M, Dunphy KA, Schneider SS, Vandenberg LN, Majhi PD, Byrne C, Trentham-Dietz A.  2018.  Genetic variation in sensitivity to estrogens and breast cancer risk. Mammalian Genome. 29:24–37.
Schneider SS, Henchey EM, Sultana N, Morin SM, Jerry JD, Makari-Judson G, Crisi GM, Arenas RB, Johnson M, Mason HS et al..  2017.  Individual-specific variation in the respiratory activities of HMECs and their bioenergetic response to IGF1 and TNFa. Journal of Cellular Physiology. 232:2750–2765.
Le NDB, Tonga GY, Mout R, Kim S-T, Wille ME, Rana S, Dunphy KA, Jerry JD, Yazdani M, Ramanathan R et al..  2017.  Cancer Cell Discrimination Using Host–Guest “Doubled” Arrays. Journal of the American Chemical Society. 139:8008–8012.
Kundu N, Domingues CC, Chou C, Ahmadi N, Houston S, Jerry JD, Sen S.  2017.  Use of p53-Silenced Endothelial Progenitor Cells to Treat Ischemia in Diabetic Peripheral Vascular Disease. Journal of the American Heart Association. 6:e005146.
Mak P, Li J, Samanta S, Chang C, Jerry JD, Davis RJ, Leav I, Mercurio AM.  2015.  Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor β repression.. Cell Rep. 10(12):1982-91.
Sturgeon SR, Arcaro KF, Johnson MA, Balasubramanian R, Zorn M, Jerry JD, Schneider SS.  2014.  DNA methylation in paired breast epithelial and white blood cells from women undergoing reduction mammoplasty.. Anticancer Res. 34(6):2985-90.
Rotunno M, Sun X, Figueroa J, Sherman ME, Garcia-Closas M, Meltzer P, Williams T, Schneider SS, Jerry JD, Yang XR et al..  2014.  Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status.. Breast Cancer Res. 16(4):R74.
Makari-Judson G, Braun B, Jerry JD, Mertens WC.  2014.  Weight gain following breast cancer diagnosis: Implication and proposed mechanisms.. World J Clin Oncol. 5(3):272-82.
Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry JD, Kung AL, Hide W, Ince TA, Lieberman J.  2013.  A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells.. Cancer Cell. 24(2):182-96.
Dunphy KA, Seo J-H, Kim DJ, Roberts AL, Tao L, Direnzo J, Balboni AL, Crisi GM, Hagen MJ, Chandrasekaran T et al..  2013.  Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation.. Cancer Cell Int. 13(1):74.
Böhringer M, Obermeier K, Griner N, Waldraff D, Dickinson E, Eirich K, Schindler D, Hagen M, Jerry DJ, Wiesmüller L.  2013.  siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.. Oncogene.
Yadava N, Schneider SS, Jerry JD, Kim C.  2013.  Impaired mitochondrial metabolism and mammary carcinogenesis.. J Mammary Gland Biol Neoplasia. 18(1):75-87.
Jerry JD, Makari-Judson G, Crisi GM, Dunphy KA.  2013.  Pregnancy offers new insights into mechanisms of breast cancer risk and resistance.. Breast Cancer Res. 15(5):312.
Tao L, Roberts AL, Dunphy KA, Bigelow C, Yan H, Jerry JD.  2011.  Repression of mammary stem/progenitor cells by p53 is mediated by Notch and separable from apoptotic activity.. Stem cells (Dayton, Ohio). 29(1):119-27.
Dunphy KA, Schneyer AL, Hagen MJ, Jerry JD.  2011.  The role of activin in mammary gland development and oncogenesis.. Journal of mammary gland biology and neoplasia. 16(2):117-26.
Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao J-H, Ravani SA, Zavadil J, Borowsky AD, Jerry JD et al..  2011.  Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type.. Cancer cell. 19(5):640-51.
Dunphy KA, Schneyer AL, Hagen MJ, Jerry JD.  2011.  The role of activin in mammary gland development and oncogenesis.. J Mammary Gland Biol Neoplasia. 16(2):117-26.
Compton S, Kim C, Griner NB, Potluri P, Scheffler IE, Sen S, Jerry JD, Schneider S, Yadava N.  2011.  Mitochondrial dysfunction impairs tumor suppressor p53 expression/function.. J Biol Chem. 286(23):20297-312.
Jerry JD, Dunphy KA, Hagen MJ.  2010.  Estrogens, regulation of p53 and breast cancer risk: a balancing act.. Cellular and molecular life sciences : CMLS. 67(7):1017-23.
Yan H, Blackburn AC, McLary CS, Tao L, Roberts AL, Xavier EA, Dickinson ES, Seo JH, Arenas RB, Otis CN et al..  2010.  Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice.. Am J Pathol. 176(3):1421-32.
Jerry JD, Dunphy KA, Hagen MJ.  2010.  Estrogens, regulation of p53 and breast cancer risk: a balancing act.. Cell Mol Life Sci. 67(7):1017-23.
Dunphy KA, Tao L, Jerry JD.  2010.  Mammary epithelial transplant procedure.. Journal of visualized experiments : JoVE. (40)
Tchatchou S, Riedel A, Lyer S, Schmutzhard J, Strobel-Freidekind O, Gronert-Sum S, Mietag C, D'Amato M, Schlehe B, Hemminki K et al..  2010.  Identification of a DMBT1 polymorphism associated with increased breast cancer risk and decreased promoter activity.. Hum Mutat. 31(1):60-6.
Yan H, Blackburn AC, McLary CS, Tao L, Roberts AL, Xavier EA, Dickinson ES, Seo JH, Arenas RB, Otis CN et al..  2010.  Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice.. The American journal of pathology. 176(3):1421-32.
Bajaj A, Miranda OR, Phillips R, Kim I-B, Jerry JD, Bunz UHF, Rotello VM.  2010.  Array-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.. Journal of the American Chemical Society. 132(3):1018-22.
Cellurale C, Weston CR, Reilly J, Garlick DS, Jerry JD, Sluss HK, Davis RJ.  2010.  Role of JNK in a Trp53-dependent mouse model of breast cancer.. PLoS One. 5(8):e12469.
Bajaj A, Miranda OR, Phillips R, Kim I-B, Jerry JD, Bunz UHF, Rotello VM.  2010.  Array-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.. J Am Chem Soc. 132(3):1018-22.
Troester MA, Lee MH, Carter M, Fan C, Cowan DW, Perez ER, Pirone JR, Perou CM, Jerry JD, Schneider SS.  2009.  Activation of host wound responses in breast cancer microenvironment.. Clin Cancer Res. 15(22):7020-8.
Roy R, Jerry JD, Thayumanavan S.  2009.  Virus-inspired approach to nonviral gene delivery vehicles.. Biomacromolecules. 10(8):2189-93.
Bajaj A, Miranda OR, Kim I-B, Phillips RL, Jerry JD, Bunz UHF, Rotello VM.  2009.  Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays.. Proc Natl Acad Sci U S A. 106(27):10912-6.
Bajaj A, Miranda OR, Kim I-B, Phillips RL, Jerry JD, Bunz UHF, Rotello VM.  2009.  Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays.. Proceedings of the National Academy of Sciences of the United States of America. 106(27):10912-6.
Roy R, Jerry JD, Thayumanavan S.  2009.  Virus-inspired approach to nonviral gene delivery vehicles.. Biomacromolecules. 10(8):2189-93.
Lu S, Becker KA, Hagen MJ, Yan H, Roberts AL, Mathews LA, Schneider SS, Siegelmann HT, MacBeth KJ, Tirrell SM et al..  2008.  Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity.. Endocrinology. 149(10):4809-20.
Jerry JD, Tao L, Yan H.  2008.  Regulation of cancer stem cells by p53.. Breast Cancer Res. 10(4):304.
Samanta B, Yan H, Fischer NO, Shi J, Jerry JD, Rotello VM.  2008.  Protein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.. J Mater Chem. 18(11):1204-1208.
Jerry JD, Tao L, Yan H.  2008.  Regulation of cancer stem cells by p53.. Breast cancer research : BCR. 10(4):304.
Lu S, Becker KA, Hagen MJ, Yan H, Roberts AL, Mathews LA, Schneider SS, Siegelmann HT, MacBeth KJ, Tirrell SM et al..  2008.  Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity.. Endocrinology. 149(10):4809-20.
Dunphy KA, Blackburn AC, Yan H, O'Connell LR, Jerry JD.  2008.  Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice.. Breast cancer research : BCR. 10(3):R43.
Koch JG, Gu X, Han Y, El-Naggar AK, Olson MV, Medina D, Jerry JD, Blackburn AC, Peltz G, Amos CI et al..  2007.  Mammary tumor modifiers in BALB/cJ mice heterozygous for p53.. Mamm Genome. 18(5):300-9.
Blackburn AC, Hill LZ, Roberts AL, Wang J, Aud D, Jung J, Nikolcheva T, Allard J, Peltz G, Otis CN et al..  2007.  Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.. Am J Pathol. 170(6):2030-41.
Blackburn AC, Hill LZ, Roberts AL, Wang J, Aud D, Jung J, Nikolcheva T, Allard J, Peltz G, Otis CN et al..  2007.  Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.. The American journal of pathology. 170(6):2030-41.
Tu Y, Jerry JD, Pazik B, Schneider SS.  2005.  Sensitivity to DNA damage is a common component of hormone-based strategies for protection of the mammary gland.. Molecular cancer research : MCR. 3(8):435-42.
Becker KA, Lu S, Dickinson ES, Dunphy KA, Mathews L, Schneider SS, Jerry JD.  2005.  Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways.. Oncogene. 24(42):6345-53.
Becker KA, Lu S, Dickinson ES, Dunphy KA, Mathews L, Schneider SS, Jerry JD.  2005.  Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways.. Oncogene. 24(42):6345-53.
Blackburn AC, McLary CS, Naeem R, Luszcz J, Stockton DW, Donehower LA, Mohammed M, Mailhes JB, Soferr T, Naber SP et al..  2004.  Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain.. Cancer research. 64(15):5140-7.
Blackburn AC, McLary CS, Naeem R, Luszcz J, Stockton DW, Donehower LA, Mohammed M, Mailhes JB, Soferr T, Naber SP et al..  2004.  Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain.. Cancer Res. 64(15):5140-7.
Blackburn AC, Brown JS, Naber SP, Otis CN, Wood JT, Jerry JD.  2003.  BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.. Cancer research. 63(10):2364-8.
Blackburn AC, Brown JS, Naber SP, Otis CN, Wood JT, Jerry JD.  2003.  BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.. Cancer Res. 63(10):2364-8.
Blackburn AC, Jerry JD.  2002.  Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer? Breast cancer research : BCR. 4(3):101-11.
Jerry JD, Minter LM, Becker KA, Blackburn AC.  2002.  Hormonal control of p53 and chemoprevention.. Breast cancer research : BCR. 4(3):91-4.
Jerry JD, Minter LM, Becker KA, Blackburn AC.  2002.  Hormonal control of p53 and chemoprevention.. Breast Cancer Res. 4(3):91-4.
Jerry DJ, Dickinson ES, Roberts AL, Said TK.  2002.  Regulation of apoptosis during mammary involution by the p53 tumor suppressor gene.. J Dairy Sci. 85(5):1103-10.
Minter LM, Dickinson ES, Naber SP, Jerry JD.  2002.  Epithelial cell cycling predicts p53 responsiveness to gamma-irradiation during post-natal mammary gland development.. Development (Cambridge, England). 129(12):2997-3008.
Jerry DJ, Dickinson ES, Roberts AL, Said TK.  2002.  Regulation of apoptosis during mammary involution by the p53 tumor suppressor gene.. Journal of dairy science. 85(5):1103-10.
Kasinathan P, Knott JG, Moreira PN, Burnside AS, Jerry DJ, Robl JM.  2001.  Effect of fibroblast donor cell age and cell cycle on development of bovine nuclear transfer embryos in vitro.. Biology of reproduction. 64(5):1487-93.
Kasinathan P, Knott JG, Wang Z, Jerry DJ, Robl JM.  2001.  Production of calves from G1 fibroblasts.. Nat Biotechnol. 19(12):1176-8.
Kasinathan P, Knott JG, Wang Z, Jerry DJ, Robl JM.  2001.  Production of calves from G1 fibroblasts.. Nature biotechnology. 19(12):1176-8.
Jerry DJ, Kittrell FS, Kuperwasser C, Laucirica R, Dickinson ES, Bonilla PJ, Butel JS, Medina D.  2000.  A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development.. Oncogene. 19(8):1052-8.
Kuperwasser C, Pinkas J, Hurlbut GD, Naber SP, Jerry DJ.  2000.  Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment.. Cancer research. 60(10):2723-9.
Jerry DJ, Kittrell FS, Kuperwasser C, Laucirica R, Dickinson ES, Bonilla PJ, Butel JS, Medina D.  2000.  A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development.. Oncogene. 19(8):1052-8.
Kuperwasser C, Hurlbut GD, Kittrell FS, Dickinson ES, Laucirica R, Medina D, Naber SP, Jerry DJ.  2000.  Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome.. Am J Pathol. 157(6):2151-9.
Kuperwasser C, Hurlbut GD, Kittrell FS, Dickinson ES, Laucirica R, Medina D, Naber SP, Jerry DJ.  2000.  Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome.. The American journal of pathology. 157(6):2151-9.
Pinkas J, Naber SP, Butel JS, Medina D, Jerry DJ.  1999.  Expression of MDM2 during mammary tumorigenesis.. Int J Cancer. 81(2):292-8.
Jerry DJ, Pinkas J, Kuperwasser C, Dickinson ES, Naber SP.  1999.  Regulation of p53 and its targets during involution of the mammary gland.. J Mammary Gland Biol Neoplasia. 4(2):177-81.
Pinkas J, Naber SP, Butel JS, Medina D, Jerry DJ.  1999.  Expression of MDM2 during mammary tumorigenesis.. International journal of cancer. Journal international du cancer. 81(2):292-8.
Jerry DJ, Pinkas J, Kuperwasser C, Dickinson ES, Naber SP.  1999.  Regulation of p53 and its targets during involution of the mammary gland.. Journal of mammary gland biology and neoplasia. 4(2):177-81.
Medina D, Stephens LC, Bonilla PJ, Hollmann CA, Schwahn D, Kuperwasser C, Jerry DJ, Butel JS, Meyn RE.  1998.  Radiation-induced tumorigenesis in preneoplastic mouse mammary glands in vivo: significance of p53 status and apoptosis.. Mol Carcinog. 22(3):199-207.
Jerry DJ, Kuperwasser C, Downing SR, Pinkas J, He C, Dickinson E, Marconi S, Naber SP.  1998.  Delayed involution of the mammary epithelium in BALB/c-p53null mice.. Oncogene. 17(18):2305-12.
Zawada WM, Cibelli JB, Choi PK, Clarkson ED, Golueke PJ, Witta SE, Bell KP, Kane J, Ponce de Leon FA, Jerry DJ et al..  1998.  Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats.. Nat Med. 4(5):569-74.
Cibelli JB, Stice SL, Golueke PJ, Kane JJ, Jerry J, Blackwell C, Ponce de León FA, Robl JM.  1998.  Cloned transgenic calves produced from nonquiescent fetal fibroblasts.. Science. 280(5367):1256-8.
Cibelli JB, Stice SL, Golueke PJ, Kane JJ, Jerry J, Blackwell C, Ponce de León FA, Robl JM.  1998.  Transgenic bovine chimeric offspring produced from somatic cell-derived stem-like cells.. Nat Biotechnol. 16(7):642-6.
Jerry DJ, Kuperwasser C, Downing SR, Pinkas J, He C, Dickinson E, Marconi S, Naber SP.  1998.  Delayed involution of the mammary epithelium in BALB/c-p53null mice.. Oncogene. 17(18):2305-12.
Jones FE, Jerry DJ, Guarino BC, Andrews GC, Stern DF.  1996.  Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli.. Cell Growth Differ. 7(8):1031-8.
Jerry DJ, Medina D, Butel JS.  1994.  p53 mutations in COMMA-D cells.. In Vitro Cell Dev Biol Anim. 30A(2):87-9.
Jerry DJ, Butel JS, Donehower LA, Paulson EJ, Cochran C, Wiseman RW, Medina D.  1994.  Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.. Mol Carcinog. 9(3):175-83.
Jerry DJ, Ozbun MA, Kittrell FS, Lane DP, Medina D, Butel JS.  1993.  Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development.. Cancer Res. 53(14):3374-81.
Jerry DJ, Griel LC, Kavanaugh JF, Kensinger RS.  1991.  Binding and bioactivity of ovine and porcine prolactins in porcine mammary tissue.. J Endocrinol. 130(1):43-51.
Birkenmeier EH, Gwynn B, Howard S, Jerry J, Gordon JI, Landschulz WH, McKnight SL.  1989.  Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.. Genes Dev. 3(8):1146-56.
Jerry DJ, Stover RK, Kensinger RS.  1989.  Quantitation of prolactin-dependent responses in porcine mammary explants.. J Anim Sci. 67(4):1013-9.
Name Phone Office
Sharma , Aman ABBS Graduate Student 413-545-1129 ISB 465A
Black , Amye MCB Graduate Student 413-545-1129 ISB 465A
GÖRAL , Ceren Ph.D Candidate 413-545-1129 ISB 465A
Majhi , Prabin Kumar Dhangada Postdoctoral Fellow 413-545-1129 ISB 465A
Hagen , Mary Research Technician 413-545-1129 ISB 465A
Roberts , Amy Research Technician 413-545-1129 ISB 465A
Carmichael , Taylor Undergraduate Student 413-545-1129 ISB 465A
McCarthy , Jordan Undergraduate Student 413-545-1129 ISB 465A
Ssebyala , Shakirah Undergraduate Student 413-545-1129 ISB 465A
Taylor , Noah M.Undergraduate Student 413-545-1129 ISB 465A