Defining the Role of RBBP4 in Oocyte Maturation and Preimplantation Development using Trim-away

Holly Barletta, MS Candidate in the Cui Lab will present her Master’s Thesis on Tuesday, May 11th, 4-5 PM. Join via Zoom.

Based on a previous collaboration between the Mager Lab and the Cui lab (, RBBP4 was shown to be essential for mouse early embryogenesis. To expand the knowledge of RBBP4 function during oocyte maturation and preimplantation development, Trim-Away, which is a new, acute, and endogenous protein depletion technique that can overcome limitations of CRISPR/Cas9 and RNAi, was applied in this project. Using Trim-Away offers opportunities to study new functions of RBBP4 and its maternal effect, and increase the knowledge on this new protein depletion technique.