"Negative regulation of the tumor suppressor protein p53 by deficiency of oxidative phosphorylation"

Negative regulation of the tumor suppressor protein p53 by deficiency of oxidative phosphorylation”

Dr. Nayendra Yadava
Pioneer Valley Life Science Institute
Wed, 2/13/2013 - 4:00pm

221 Integrated Sciences Building

Overview: Mitochondrial function is one of the most fundamental of cellular functions. Impaired mitochondrial function results in a host of diseases with nerves and muscle being among the tissues most sensitive. While inherited severe impairment of mitochondrial respiration is infrequent, a decline in mitochondrial function is observed with aging and obesity. Many environmental chemicals are also toxic to mitochondrial enzymes. Dr. Yadava’s recent work has demonstrated that impairment of mitochondria disrupts tumor suppressor pathways suggesting that this may be a common basis for age-associated increases in the incidence of cancer.

Find more information at: Impaired Mitochondrial Metabolism and Mammary Carcinogenesis.

Yadava N, Schneider SS, Jerry DJ, Kim C.J Mammary Gland Biol Neoplasia. 2012 Dec 27. [Epub ahead of print] PMID: 23269521
Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. Compton S, Kim C, Griner NB, Potluri P, Scheffler IE, Sen S, Jerry DJ, Schneider S, Yadava N. J Biol Chem. 2011 Jun 10;286(23):20297-312. doi: 10.1074/jbc.M110.163063. Epub 2011 Apr 18. PMID:21502317
Quantitative microplate-based respirometry with correction for oxygen diffusion. Gerencser AA, Neilson A, Choi SW, Edman U, Yadava N, Oh RJ, Ferrick DA, Nicholls DG, Brand MD. Anal Chem. 2009 Aug 15;81(16):6868-78. doi: 10.1021/ac900881z. PMID: 19555051
Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.Chinta SJ, Rane A, Yadava N, Andersen JK, Nicholls DG, Polster BM. Free Radic Biol Med. 2009 Apr 1;46(7):939-47. PMID 19280713
Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Amo T, Yadava N, Oh R, Nicholls DG, Brand MD. Gene. 2008 Mar 31;411(1-2):69-76. doi: 10.1016/j.gene.2008.01.007. Epub 2008 Jan 26. PMID: 18280061
Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly. Yadava N, Potluri P, Scheffler IE. Int J Biochem Cell Biol. 2008;40(3):447-60. Epub 2007 Sep 6. PMID: 17931954
Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. Yadava N, Nicholls DG. J Neurosci. 2007 Jul 4;27(27):7310-7. PMID: 17611283
Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity. Nicholls DG, Johnson-Cadwell L, Vesce S, Jekabsons M, Yadava N. J Neurosci Res. 2007 Nov 15;85(15):3206-12. Review. PMID: 17455297

Notes: 

Refreshments at 3:45pm