"Novel regulators of liver development and regeneration"

Novel regulators of liver development and regeneration”

Wolfram Goessling, M.D, Ph.D.
Harvard Medical School
Wed, 9/24/2014 - 4:00pm

221 Integrated Sciences Building

Developmental signaling pathways govern the formation and function of stem cells, thereby holding the key to unlocking the promise of adult tissue regeneration, and to inhibiting cancer development. In our laboratory, we use zebrafish as the primary model to study the liver and explore the regulation of endodermal progenitor cell specification, organ differentiation and growth. We then examine the conserved role of these signaling pathways in regulating tissue growth in surgical and chemical models of liver regeneration and genetic liver cancer models. We also use murine liver injury models to demonstrate evolutionary conservation and relevance for human disease. Our prior work has shown that we can translate our findings from the fish tank to the bedside, as the first clinical trial originating from our findings in the fish has begun to enroll patients.

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Refreshments at 3:45pm