"How to build new organs from old cells: using the amphibian limb regenerate to study endogenous cell reprogramming”

How to build new organs from old cells: using the amphibian limb regenerate to study endogenous cell reprogramming”

Kate McCusker, Ph.D.
UC Irvine
Wed, 10/8/2014 - 4:00pm

221 Integrated Sciences Building

Salamanders have the amazing capacity to dedifferentiate and reprogram adult somatic cells to generate a pool of progenitor cells (called blastema cells) that will replace missing structures, such as amputated limbs. In this talk I will discuss how the tissue microenvironment controls the reprogramming of pattern information in limb blastema cells, and how this process can be manipulated in a predictable way. I will then discuss how what we have learned about amphibian limb regeneration could apply to improving cell-based regenerative medicine in humans.

Notes: 

Refreshments at 3:45pm