Gayatri Mohanty

Postdotoral Research Associate

Office: 

ISB 465A

Phone: 

413-545-4050

Email: 
gmohanty [at] umass [dot] edu

Gayatri received her bachelor’s degree from Utkal University in India majoring in Zoological Sciences. She earned her Master’s degree from Ravenshaw University, India with specializations in Cell Physiology and Biochemistry. She earned her doctoral degree from Ravenshaw University, India studying the effect of dysregulated proteins on redox metabolics of human spermatozoa in different pathological states through the implementation of high-throughput proteomics technology. Being a Gold-medallist in her Master’s degree program, her doctoral research was funded by Department of Science and Technology, Government of India (GOI) under the INSPIRE program. As a part of her doctoral program she was a visiting scholar at the American Center for Reproductive Medicine at the Cleveland Clinic in Ohio and received hands-on training in basic andrology techniques. She is also the recipient of the prestigious Professor N.R. Moudgal Young Scientist Award (2017) for her scientific contributions to reproductive health. In addition, she received a post-doctoral fellowship from Council of Scientific and Industrial Research, GOI and University Grants Commission, GOI. During her post-doctoral research in India she investigated the paternal effects of dysregulated proteins in recurrent pregnancy loss patients using various proteomics and bioinformatics tools. Recently, based upon her research credentials, she was awarded the Corporate Member Council In Training Travel Award by the American Society for Reproductive Medicine (2019). Gayatri’s research in the Visconti lab, in collaboration with the Pilsner lab, focuses on the toxicological effects of phthalates on sperm capacitation and fertilization. It is hoped that this research will help to gain knowledge as to how preconception environmental exposures in males during spermatogenesis may contribute to adverse reproductive health outcomes. Her research interests also include understanding the downstream signalling mechanism of calcium influx through CATSPER channels in the sperm plasma membrane which is important for fertilization and embryo development. In addition, her research focuses on the assessment of sperm energy flux post-ejaculation that fuels the spermatozoa to fertilize the ovum and thus improve the assisted reproductive technology outcome. Her future interest is in identifying the molecular markers that lead to adverse reproductive health outcome and whether manipulation of these could eventually lead to designing a potential male contraceptive.

Publications:
• Mohanty G, JenaSR, Nayak J, Kar S, Samanta L (2020). Quantitative Proteomics Decodes Clusterin As a Critical Regulator of Paternal Factors Responsible For Impaired Compensatory Metabolic Reprogramming in Recurrent Pregnancy Loss. Andrologia. 52:e13498.

• Mohanty G, JenaSR, Nayak J, Kar S, Samanta L (2020). Proteomic Signatures in Spermatozoa Reveal the Role of Paternal Factors in Recurrent Pregnancy Loss. World J Mens Health. 38:103-114.

• Mohanty G, Swain N, Goswami C, Kar S and Samanta L (2016). Histone retention, protein carbonylation and lipid peroxidation in spermatozoa: Possible role in recurrent pregnancy loss. SystBiol and Reprod Med. 62:201-12.

• du Plessis SS, Agarwal A, Mohanty G, van der Linde M (2015). Oxidative phosphorylation versus glycolysis: what fuel do spermatozoa use?Asian J Androl. 17:230-5.

• Mohanty G, Swain N, Samanta L (2015). Sperm Proteome: What Is on the Horizon? Reprod Sci. 22:638-53.
• Sharma R, Agarwal A, Mohanty G, Jesudasan R, Gopalan B, Willard B, Yadav S, Sabanegh E (2013). Functional proteomic analysis of seminal plasma proteins in men with various semen parameter. ReprodBiolEndocrinol. 11:38.

• Sharma R, Agarwal A, Mohanty G, Hamada A, Gopalan B, Willard B, Yadav S and du Plessis S (2013). Proteomic analysis of human spermatozoa proteins with oxidative stress. ReprodBiolEndocrinol. 11:48.

• Sharma R, Agarwal A, Mohanty G, du Plessis SS, Gopalan B, Willard B, Yadav SP, Sabanegh E (2013). Proteomic analysis of seminal fluid from men exhibiting oxidative stress. ReprodBiolEndocrinol. 11:85.
Book Chapters
• Samanta L, Mohanty G and Agarwal A (2015). Male factors and Recurrent Pregnancy Loss. In: Recurrent Pregnancy Loss: An Evidence Based Evaluation. Bashiri A,,Harlev A, Agarwal A (EDs). Springer Publications. USA. pp:109-130. ISBN 978-3-319-27452-2.

• Mohanty G and Samanta L. Challenges of proteomic studies in human reproduction. Proteomics in Human Reproduction: Biomarkers for Millennials. Agarwal A, Samanta L, Bertollo PR, Durairaganayagam D, Intasqui P (EDs). Springer Publications. USA.ISBN 978-3-319-48416-7.

• N Swain, Mohanty G, L Samanta, P Intasqui. Proteomics and Male Infertility. Proteomics in Human Reproduction: Biomarkers for Millennials. Agarwal A, Samanta L, Bertollo PR, Durairaganayagam D, Intasqui P (EDs). Springer Publications. USA. ISBN 978-3-319-48416-7.