Constance Angelou

Ph.D Candidate, MCB


ISB 470

cangelou [at] umass [dot] edu
Former PI: 
Leonid A. Pobezinsky

Constance graduated from the Université Catholique de Louvain, Belgium, with a Bachelor’s degree in Biological Sciences and a Master’s degree in Biochemistry and Cellular and Molecular Biology. Constance’s research in the Pobezinsky lab focuses primarily on the pathways regulating CD4 T cell differentiation at the post-transcriptional levels. CD4 T cells, once activated, can differentiate into distinct subtypes of helper cells, which contribute to the immune response. Under pathological conditions, helper cells can become detrimental and cause autoimmune response. Constance explores the role of miRNAs during the differentiation of pathogenic CD4 lymphocytes using experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, an autoimmune neurodegenerative disorder. Constance is also interested in investigating the molecular mechanisms underlying the regulation of miRNAs in the context of T cell activation, differentiation and function.