Transcriptional control of T cell development.
| Title | Transcriptional control of T cell development. |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Osborne BA |
| Journal | Current opinion in immunology |
| Volume | 12 |
| Issue | 3 |
| Pagination | 301-6 |
| Date Published | 2000 Jun |
| Abstract | Transcriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally, a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted. |
| Alternate Journal | Curr. Opin. Immunol. |