The distribution of progestin receptor mRNA in rat brainstem.

TitleThe distribution of progestin receptor mRNA in rat brainstem.
Publication TypeJournal Article
Year of Publication2002
AuthorsCurran-Rauhut MA, Petersen SL
JournalBrain research. Gene expression patterns
Date Published2002 Oct
AbstractHypothalamic sites wherein P4, through progestin receptor, (Pgr; commonly abbreviated PR), maximizes the expression of female sexual behaviors and gonadotropin surge release have been studied intensively. However, little is known regarding PR expression in brainstem regions likely to regulate changes in autonomic functions observed when P4 levels are elevated (i.e. pregnancy). Using in situ hybridization, we found PR mRNA-containing cells widely distributed throughout the brainstem of ovariectomized, estradiol-treated Sprague-Dawley rats, with high expression in regions including the medial vestibular nucleus, nucleus of the solitary tract, substantia nigra (compact part), ventral tegmental area, hypoglossal nucleus, locus coeruleus, Purkinje cell layer of the cerebellum and inferior olivary complex. We also detected moderate to high levels of PR gene expression in several regions, such as the trapezoid nucleus, facial nucleus, periaqueductal gray regions, and rostral ventrolateral medulla. These results demonstrate that PR expression is widespread in the brainstem and identify nuclei wherein P4 may act to influence a number of physiological functions during pregnancy.
Alternate JournalBrain Res. Gene Expr. Patterns