Signalling pathways involved in sperm capacitation.

TitleSignalling pathways involved in sperm capacitation.
Publication TypeJournal Article
Year of Publication2007
AuthorsSalicioni AM, Platt MD, Wertheimer EV, Arcelay E, Allaire A, Sosnik J, Visconti PE
JournalSociety of Reproduction and Fertility supplement
Volume65
Pagination245-59
Date Published2007
KeywordsAcrosome Reaction, Animals, Cell Membrane, Female, Male, Mammals, Phosphorylation, Seminal Plasma Proteins, Signal Transduction, Sperm Capacitation, Spermatozoa
AbstractAfter ejaculation, mammalian sperm have not yet acquired full fertilising capacity. They will require a finite period of residence in the female reproductive tract before they become fertilisation competent. The molecular, biochemical, and physiological changes that occur to sperm while in the female tract are collectively referred to as capacitation. During capacitation, changes in membrane properties, enzyme activities, and motility render spermatozoa responsive to stimuli that induce the acrosome reaction and prepare spermatozoa for penetration of the egg investments prior to fertilisation. These changes are facilitated by the activation of cell signalling cascades in the female reproductive tract in vivo or in defined media in vitro. The purposes of this review are to consider some recent contributions towards our understanding of capacitation, to summarise open questions in this field, and to discuss future avenues of research.
Alternate JournalSoc Reprod Fertil Suppl
PubMed ID17644966