Role of JNK in a Trp53-dependent mouse model of breast cancer.

TitleRole of JNK in a Trp53-dependent mouse model of breast cancer.
Publication TypeJournal Article
Year of Publication2010
AuthorsCellurale C, Weston CR, Reilly J, Garlick DS, Jerry JD, Sluss HK, Davis RJ
JournalPLoS One
Volume5
Issue8
Paginatione12469
Date Published2010
ISSN1932-6203
KeywordsAnimals, Breast Neoplasms, Disease Models, Animal, Female, Mammary Glands, Animal, Mice, Mice, Inbred BALB C, Mitogen-Activated Protein Kinase 8, Mitogen-Activated Protein Kinase 9, Survival Analysis, Tumor Suppressor Protein p53
Abstract

The cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in mammary carcinogenesis. To test the role of JNK, we examined the effect of ablation of the Jnk1 and Jnk2 genes in a Trp53-dependent model of breast cancer using BALB/c mice. We detected no defects in mammary gland development in virgin mice or during lactation and involution in control studies of Jnk1(-/-) and Jnk2(-/-) mice. In a Trp53(-/+) genetic background, mammary carcinomas were detected in 43% of control mice, 70% of Jnk1(-/-) mice, and 53% of Jnk2(-/-) mice. These data indicate that JNK1 and JNK2 are not essential for mammary carcinoma development in the Trp53(-/+) BALB/c model of breast cancer. In contrast, this analysis suggests that JNK may partially contribute to tumor suppression. This conclusion is consistent with the finding that tumor-free survival of JNK-deficient Trp53(-/+) mice was significantly reduced compared with control Trp53(-/+) mice. We conclude that JNK1 and JNK2 can act as suppressors of mammary tumor development.

DOI10.1371/journal.pone.0012469
Alternate JournalPLoS ONE
PubMed ID20814571