Regulation of p53 and its targets during involution of the mammary gland.

TitleRegulation of p53 and its targets during involution of the mammary gland.
Publication TypeJournal Article
Year of Publication1999
AuthorsJerry DJ, Pinkas J, Kuperwasser C, Dickinson ES, Naber SP
JournalJ Mammary Gland Biol Neoplasia
Volume4
Issue2
Pagination177-81
Date Published1999 Apr
ISSN1083-3021
KeywordsAnimals, Apoptosis, Breast, Breast Neoplasms, DNA Damage, Female, Gene Expression Regulation, Genes, p53, Humans, Lactation, Mammary Glands, Animal, Tumor Suppressor Protein p53
Abstract

Post-lactational involution of the mammary gland provides a system in which to study the expression and function of genes that regulate apoptosis in the context of a normal tissue. The functions of the p53 tumor suppressor gene have been extensively studied as a mediator of apoptosis in response to DNA damage, but its regulation in normal physiologic processes has been poorly characterized. Expression of p53 mRNA was shown to be among the first genes to be induced in mammary tissue following weaning of neonates. Although involution proceeds in the absence of a functional p53 gene, it is delayed compared to normal individuals. Therefore, involution can be viewed as biphasic with initial responses being sensitive to p53, whereas secondary responses being p53-independent. These observations can be exploited to determine the subset of genes that are p53-responsive and that mediate the effects of p53 in normal mammary tissue.

Alternate JournalJ Mammary Gland Biol Neoplasia
PubMed ID10426396