Protein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.

TitleProtein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.
Publication TypeJournal Article
Year of Publication2008
AuthorsSamanta B, Yan H, Fischer NO, Shi J, Jerry JD, Rotello VM
JournalJ Mater Chem
Volume18
Issue11
Pagination1204-1208
Date Published2008
ISSN0959-9428
Abstract

Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

DOI10.1039/b718745a
Alternate JournalJ Mater Chem
PubMed ID19122852