Pregnancy offers new insights into mechanisms of breast cancer risk and resistance.

TitlePregnancy offers new insights into mechanisms of breast cancer risk and resistance.
Publication TypeJournal Article
Year of Publication2013
AuthorsJerry JD, Makari-Judson G, Crisi GM, Dunphy KA
JournalBreast Cancer Res
Volume15
Issue5
Pagination312
Date Published2013
ISSN1465-542X
KeywordsBreast Neoplasms, Cell Lineage, Cyclin-Dependent Kinase Inhibitor p27, Female, Gene Expression Profiling, Humans, Mammary Glands, Human, Parity, Pregnancy, Stem Cells
Abstract

Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent studies focus attention on progenitor cells as major targets. The results suggest new biomarkers that may improve risk prediction and provide endpoints for assessment of clinical responses to prophylactic therapies.

DOI10.1186/bcr3482
Alternate JournalBreast Cancer Res.
PubMed ID24060354