Notch signalling during peripheral T-cell activation and differentiation.
| Title | Notch signalling during peripheral T-cell activation and differentiation. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Osborne BA, Minter LM |
| Journal | Nature reviews. Immunology |
| Volume | 7 |
| Issue | 1 |
| Pagination | 64-75 |
| Date Published | 2007 Jan |
| Abstract | For many years, researchers have focused on the contribution of Notch signalling to lymphoid development. Only recently have investigators begun to ask what role, if any, Notch has during the activation and differentiation of naive CD4(+) T cells in the periphery. As interest in this issue grows, it is becoming increasingly clear that the main role of Notch signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells. |
| Alternate Journal | Nat. Rev. Immunol. |