Leukocyte-derived and endogenous matrix metalloproteinases in the lamellae of horses with naturally acquired and experimentally induced laminitis.

TitleLeukocyte-derived and endogenous matrix metalloproteinases in the lamellae of horses with naturally acquired and experimentally induced laminitis.
Publication TypeJournal Article
Year of Publication2009
AuthorsLoftus JP, Johnson PJ, Belknap JK, Pettigrew A, Black SJ
JournalVeterinary immunology and immunopathology
Volume129
Issue3-4
Pagination221-30
Date Published2009 Jun 15
AbstractInflammation and dysregulation of endogenous matrix metalloproteinase (MMP) production are implicated in the development of equine laminitis. In this study, we examine quantitative relationships among levels of leukocyte-derived proMMP-9 and MMP-9, lamellar proMMP-2 and MMP-2, and expression of proMMP-2 processing enzymes, MT1-MMP/PACE4, as steps towards determining whether inflammation and dysregulation of endogenous MMP production are independent or co-dependent processes.
Alternate JournalVet. Immunol. Immunopathol.