| Title | Expressed gene sequences of the equine cytokines interleukin-17 and interleukin-23. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Tompkins D, Hudgens E, Horohov D, Baldwin CL |
| Journal | Veterinary immunology and immunopathology |
| Volume | 133 |
| Issue | 2-4 |
| Pagination | 309-13 |
| Date Published | 2010 Feb 15 |
| Abstract | This report describes the initial cloning and characterization of the equine interleukin-17 (IL-17) expressed gene sequence from mRNA obtained from equine intestinal tissue and interleukin-23 (IL-23) expressed gene sequence from mRNA obtained from equine peripheral blood mononuclear cells. Equine IL-17 has 462 nucleotides in the translated region, determined by homology with known human and mouse sequences, and shares 84% and 75% identity, respectively. For the deduced amino acid sequences, the identity with human and mouse is 76% and 70%. Equine IL-23 has 579 nucleotides in the translated region. Homology with known human and mouse sequences was determined to be 89% and 77%. Deduced amino acid identities are 89% with the human sequence and 70% with the mouse sequence. The gene sequences were identified as part of the U.S. Veterinary Immune Reagent Network with a goal of developing reagents in order to aid veterinary researchers in the investigation of diseases in livestock species. |
| Alternate Journal | Vet. Immunol. Immunopathol. |
