Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice.

TitleEstrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice.
Publication TypeJournal Article
Year of Publication2008
AuthorsDunphy KA, Blackburn AC, Yan H, O'Connell LR, Jerry JD
JournalBreast cancer research : BCR
Volume10
Issue3
PaginationR43
Date Published2008
AbstractTreatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome.
Alternate JournalBreast Cancer Res.