Direct and indirect regulation of gonadotropin-releasing hormone neurons by estradiol.

TitleDirect and indirect regulation of gonadotropin-releasing hormone neurons by estradiol.
Publication TypeJournal Article
Year of Publication2003
AuthorsPetersen SL, Ottem EN, Carpenter CD
JournalBiology of reproduction
Volume69
Issue6
Pagination1771-8
Date Published2003 Dec
AbstractEstrogen signaling to GnRH neurons is critical for coordinating the preovulatory surge release of LH with follicular maturation. Until recently it was thought that estrogen signaled GnRH neurons only indirectly through numerous afferent systems. This minireview presents new evidence indicating that GnRH neurons are directly regulated by estradiol (E2), primarily through estrogen receptor (ER)-beta, and indirectly through E2-sensitive neurons in the anteroventral periventricular (AVPV) region. The data described suggest that E2 generally represses GnRH gene expression but that this repression is transiently overcome by indirect E2-dependent signals relayed by AVPV neurons. We also present evidence that the AVPV neurons responsible for relaying E2 signals to GnRH neurons are multifunctional gamma aminobutyric acid-ergic/glutamatergic/neuropeptidergic neurons.
Alternate JournalBiol. Reprod.