Complexity of polycomb group function: diverse mechanisms of target specificity.

TitleComplexity of polycomb group function: diverse mechanisms of target specificity.
Publication TypeJournal Article
Year of Publication2011
AuthorsTrask MC, Mager J
JournalJournal of cellular physiology
Date Published2011 Jul
KeywordsAnimals, Binding Sites, DNA, Embryo, Mammalian, Epigenesis, Genetic, Gene Expression Regulation, Developmental, Gene Silencing, Humans, Protein Binding, Repressor Proteins, RNA, Untranslated, Signal Transduction
AbstractEpigenetic regulation of gene expression has become relevant to nearly all areas of biomedical research. The emergence of technologies that allow for examination of the epigenome combined with identification of key protein complexes that mediate the myriad chromatin modifications that occur have greatly enhanced the versatility and efficacy of tools with which to study normal development and disease states. The evolutionarily conserved polycomb group genes (PcG) have been identified as a predominant mechanism by which gene silencing occurs during development, differentiation, and disease. While molecular events that target PcG complexes have been well defined in some non-vertebrate models, the details of locus specificity and functional diversity of mammalian PcG proteins have not yet unresolved. Here we discuss recent findings that offer novel mechanistic events and add complexity to our understanding of PcG function in vertebrates.
Alternate JournalJ. Cell. Physiol.
PubMed ID20799281