Array-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.

TitleArray-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.
Publication TypeJournal Article
Year of Publication2010
AuthorsBajaj A, Miranda OR, Phillips R, Kim I-B, Jerry JD, Bunz UHF, Rotello VM
JournalJournal of the American Chemical Society
Volume132
Issue3
Pagination1018-22
Date Published2010 Jan 27
AbstractA family of conjugated fluorescent polymers was used to create an array for cell sensing. Fluorescent conjugated polymers with pendant charged residues provided multivalent interactions with cell membranes, allowing the detection of subtle differences between different cell types on the basis of cell surface features. Highly reproducible characteristic patterns were obtained from different cell types as well as from isogenic cell lines, enabling the identification of the cell type as well differentiating between normal, cancerous, and metastatic isogenic cell types with high accuracy.
Alternate JournalJ. Am. Chem. Soc.